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US Patent 11859225 Methods of producing epimerases and benzylisoquinoline alkaloids

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 US Patent 11859225 Methods of producing epimerases and benzylisoquinoline alkaloids

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Patent abstract

A method of epimerizing an (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid is provided. The method comprises contacting the (S)-1-benzylisoquinoline alkaloid with at least one enzyme. Contacting the (S)-1-benzylisoquinoline alkaloid with the at least one enzyme converts the (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid.

Infobox
Is a
Patent
Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
118592250
Patent Inventor Names
Catherine Thodey0
Christina D. Smolke0
Isis Trenchard0
Stephanie Galanie0
Yanran Li0
Date of Patent
January 2, 2024
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Patent Application Number
155673580
Date Filed
May 9, 2016
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Patent Citations
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US Patent 7193127 Codeinone reductase from alkaloid poppy
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US Patent 7390642 Salutaridinol 7-O-acetyltransferase and derivatives thereof
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US Patent 7514251 O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in
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US Patent 7767428 Salutaridinol 7-
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US Patent 8318474 Engineered yeast cells and uses thereof
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US Patent 8710226 Process for the preparation of morphinane analogues
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US Patent 8735111 Processes for producing hydrocarbon products
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US Patent 8975063 Compositions and methods for producing benzylisoquinoline alkaloids
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US Patent 8993280 Method for producing alkaloids
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US Patent 9200261 Plant cytochrome P450
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US Patent 9322039 Compositions and methods for producing benzylisoquinoline alkaloids
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US Patent 9376696 Compositions and methods for producing benzylisoquinoline alkaloids
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US Patent 9447444 Biosynthesis of opiate alkaloids
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US Patent 9458481 Methyltransferase nucleic acids and polypeptides
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US Patent 9534241 Benzylisoquinoline alkaloids (BIA) producing microbes, and methods of making and using the same
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US Patent 9725732 Plant cytochrome P450
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US Patent 9862979 Biosynthesis of opiate alkaloids
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US Patent 9926329 Acetate salt of buprenorphine and methods for preparing buprenorphine
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US Patent 10006010 Cytochrome P450 fusion protein
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US Patent 10017799 Benzylisoquinoline alkaloids (BIA) producing microbes, and methods of making and using the same
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US Patent 10190141 Compositions and methods for making (R)-Reticuline and precursors thereof
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US Patent 10519453 Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same
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US Patent 10752093 Register and vehicle
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US Patent 6949645 Process for the production of opiates
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US Patent 7037674 Cytochrome P450 reductases from poppy plants
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US Patent 7045290 Yeast screens for treatment of human disease
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Patent Primary Examiner
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Robert B Mondesi
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CPC Code
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C12P 17/188
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C12P 17/12
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C12N 9/1007
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C12Y 201/01075
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