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US Patent 11851648 Humanized cell line

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Patent Citations Received
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US Patent 12122807 Influenza virus replication for vaccine development
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US Patent 12076387 Vaccines comprising mutant attenuated influenza viruses
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 US Patent 11851648 Humanized cell line

Article

Patent abstract

A mammalian or avian cell line that expresses high levels of human influenza virus receptors is provided. In one embodiment, the cell line supports human influenza virus, e.g., human A/H3 influenza virus, isolation and growth much more effectively than corresponding conventional (unmodified) cells or in corresponding human virus receptor-overexpressing cells, and the propagated viruses may maintain higher genetic stability than in the corresponding cells.

Infobox
Is a
Patent
Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
118516480
Patent Inventor Names
Kosuke Takada0
Masaki Imai0
Yoshihiro Kawaoka0
Date of Patent
December 26, 2023
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Patent Application Number
167854490
Date Filed
February 7, 2020
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Patent Citations
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US Patent 7176021 Mutant cells with altered sialic acid
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US Patent 7211378 Filovirus vectors and noninfectious filovirus-based particles
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US Patent 7226774 Signal for packaging of influenza virus vectors
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US Patent 7312064 DNA transfection system for the generation of infectious influenza virus
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US Patent 7335356 Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein
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US Patent 11180737 Generation of infectious influenza viruses from virus-like particles
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US Patent 7507411 Attenuated influenza NS1 variants
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US Patent 7566458 Influenza hemagglutinin and neuraminidase variants
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US Patent 7585657 Signal for packaging of influenza virus vector
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US Patent 7588769 Viruses encoding mutant membrane protein
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US Patent 7601356 Methods and compositions for increasing replication capacity of an influenza virus
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US Patent 7670837 Non-tumorigenic MDCK cell line for propagating viruses
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US Patent 7682618 Generation of virus-like particles and use as panfilovirus vaccine
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US Patent 7723094 Recombinant influenza vectors with a polII promoter and ribozymes for vaccines and gene therapy
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US Patent 7833788 Production of vaccines
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US Patent 7883844 Method for propagating influenza virus
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US Patent 7955833 Animal protein free media for cultivation of cells
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US Patent 7972843 DNA-transfection system for the generation of infectious influenza virus
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US Patent 7993924 cDNA corresponding to the antigenome of nonsegmented negative stranded RNA viruses and process for the production of such viruses
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US Patent 8012736 Multi plasmid system for the production of influenza virus
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US Patent 8043856 Adenoviral vectors for influenza virus production
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US Patent 8048430 Influenza hemagglutinin and neuraminidase variants
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US Patent 8114415 Method for producing temperature sensitive influenza A viruses
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US Patent 8119337 Decreasing potential iatrogenic risks associated with influenza vaccines
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US Patent 8119388 Non-tumorigenic MDCK cell line for propagating viruses
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US Patent 8298805 Signal for packaging of influenza virus vectors
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US Patent 8309099 DNA transfection system for the generation of negative strand RNA virus
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US Patent 8354114 Multi plasmid system for the production of influenza virus
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US Patent 8357376 Method of purifying influenza virus and removing MDCK cell DNA contaminants
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US Patent 8409843 Multi plasmids system for the production of influenza virus
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US Patent 8460914 Decreasing potential iatrogenic risks associated with vaccines and vaccine antigens
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US Patent 8465960 Influenza B viruses with reduced sensitivity to neuraminidase inhibitors
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US Patent 8475806 High titer recombinant influenza viruses for vaccines and gene therapy
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US Patent 8507247 Influenza A virus with attenuating mutations in NS2 protein
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US Patent 8524497 Animal protein free media for cultivation of cells
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US Patent 8546123 Production of poliovirus at high titers for vaccine production
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US Patent 8574591 Multi plasmid system for the production of influenza virus
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US Patent 8574593 Influenza hemagglutinin and neuraminidase variants
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US Patent 11197925 Influenza B virus replication for vaccine development
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US Patent 11197926 Recombinant influenza viruses with stabilized HA for replication in eggs
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US Patent 8580277 Influenza hemagglutinin and neuraminidase variants
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US Patent 8591914 Influenza hemagglutinin and neuraminidase variants
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US Patent 8597661 Neuraminidase-deficient live influenza vaccines
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US Patent 8679819 Mutant cells with altered sialic acid
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US Patent 8877209 Recombinant influenza vectors with tandem transcription units
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US Patent 8900595 Filovirus vectors and noninfectious filovirus-based particles
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US Patent 9101653 Influenza viruses with mutant PB2 gene segment as live attenuated vaccines
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US Patent 9109013 High titer recombinant influenza viruses with enhanced replication in vero cells
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US Patent 9222118 Screen for inhibitors of filovirus and uses therefor
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US Patent 9254318 High titer recombinant influenza viruses for vaccines
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US Patent 9284533 Influenza virus mutants and uses therefor
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US Patent 9474798 Influenza M2 protein mutant viruses as live influenza attenuated vaccines
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US Patent 9757446 Influenza virus vectors and uses therefor
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US Patent 9890363 Influenza virus replication for vaccine development
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US Patent 9926535 High titer recombinant influenza viruses for vaccines
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US Patent 9950057 High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
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US Patent 10053671 Mutations that confer genetic stability to additional genes in influenza viruses
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US Patent 10059925 High titer recombinant influenza viruses with enhanced replication in vero cells
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US Patent 10119124 Influenza M2 protein mutant viruses as live influenza attenuated vaccines
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US Patent 10130697 Vaccines comprising mutant attenuated influenza viruses
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US Patent 10172934 High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
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US Patent 10246686 Influenza virus replication for vaccine development
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US Patent 10358630 Recombinant influenza vectors with tandem transcription units
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US Patent 10494613 Generation of infectious influenza viruses from virus-like particles
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US Patent 10513692 Influenza viruses with mutant PB2 segment as live attenuated vaccines
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US Patent 10633422 Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
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US Patent 10808229 High titer recombinant influenza viruses with enhanced replication in vero cells
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US Patent 11241492 Mutations that confer genetic stability to genes in influenza viruses
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US Patent 11007262 Vaccines comprising mutant attenuated influenza viruses
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US Patent 11046934 Mutations that confer genetic stability to additional genes in influenza viruses
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US Patent 11384339 Influenza viruses with mutant PB2 gene segment as live attenuated vaccines
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US Patent 11389523 Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein
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US Patent 11390649 Influenza virus replication for vaccine development
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US Patent 6843996 Immunogenic composition comprising an influenza virus with a temperature sensitive PB2 mutation
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US Patent 6890710 Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication
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US Patent 6951752 Method for large scale production of virus antigen
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US Patent 6951754 DNA transfection system for the generation of infectious influenza virus
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US Patent 6974695 Complementing cell lines
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US Patent 7037707 Method for generating influenza viruses and vaccines
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Patent Primary Examiner
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Suzanne M Noakes
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