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US Patent 12076387 Vaccines comprising mutant attenuated influenza viruses

Patent 12076387 was granted and assigned to Wisconsin Alumni Research Foundation on September, 2024 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
Wisconsin Alumni Research Foundation
Wisconsin Alumni Research Foundation
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Current Assignee
Wisconsin Alumni Research Foundation
Wisconsin Alumni Research Foundation
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120763870
Patent Inventor Names
Shinji Watanabe0
Tokiko Watanabe0
Yoshihiro Kawaoka0
Date of Patent
September 3, 2024
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Patent Application Number
172290010
Date Filed
April 13, 2021
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Patent Citations
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US Patent 7037707 Method for generating influenza viruses and vaccines
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US Patent 7176021 Mutant cells with altered sialic acid
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US Patent 7211378 Filovirus vectors and noninfectious filovirus-based particles
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US Patent 7226774 Signal for packaging of influenza virus vectors
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US Patent 7312064 DNA transfection system for the generation of infectious influenza virus
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US Patent 7335356 Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein
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US Patent 7507411 Attenuated influenza NS1 variants
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US Patent 7566458 Influenza hemagglutinin and neuraminidase variants
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...
Patent Primary Examiner
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Stacy B. Chen
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Patent abstract

The invention provides a vaccine comprising an effective amount of an isolated recombinant influenza virus comprising a mutant M gene segment that is mutated so that upon viral replication the mutant M gene expresses a functional M1 protein and a mutant M2 protein with a deletion of the cytoplasmic tail and either lacking a transmembrane domain or having a mutated transmembrane domain.

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