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US Patent 11771775 Pyrrolobenzodiazepine-antibody conjugates

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 US Patent 11771775 Pyrrolobenzodiazepine-antibody conjugates

Article

Patent abstract

Conjugates of an antibody that binds to CD19 with PBD dimers.

Infobox
Is a
Patent
Patent
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11771775
Patent Inventor Names
Patricius Hendrikus Cornelis Van Berkel
Philip Wilson Howard
Date of Patent
October 3, 2023
Patent Application Number
16934319
Date Filed
July 21, 2020
Patent Citations
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US Patent 7223837 Elongated and multiple spacers in activatible prodrugs
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US Patent 7244724 Pyrrolobenzodiazepines
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US Patent 7265105 Pyrrolobenzodiazepines
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US Patent 7375078 Heterocyclic self-immolative linkers and conjugates
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US Patent 7407951 Pyrrolobenzodiazepines
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US Patent 7429658 Synthesis of protected pyrrolobenzodiazepines
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US Patent 7498298 Monomethylvaline compounds capable of conjugation to ligands
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US Patent 7511032 Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
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US Patent 7521541 Cysteine engineered antibodies and conjugates
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US Patent 7528126 Pyrrolobenzodiazepines
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US Patent 7557099 Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
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US Patent 7612062 Pyrrolobenzodiazepines
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US Patent 7704924 Library of compounds comprising pyrrolobenzodiazepine moieties
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US Patent 7723485 Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates
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US Patent 7741319 11-hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
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US Patent 8034808 Therapeutic compositions containing at least one pyrrolobenzodiazepine derivative and fludarabine
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US Patent 8163736 Cytotoxic agents comprising new tomaymycin derivatives
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US Patent 8487092 Pyrrolobenzodiazepines
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US Patent 8501934 Pyrrolobenzodiazepines
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US Patent 8592576 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases
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US Patent 8633185 Pyrrolobenzodiazepines
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US Patent 8637664 Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease
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US Patent 8697688 Pyrrolobenzodiazepines used to treat proliferative diseases
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US Patent 8829184 Intermediates useful for the synthesis of pyrrolobenzodiazepines
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US Patent 8940733 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases
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US Patent 9321774 Pyrrolobenzodiazepines
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US Patent 9376440 Pyrrolobenzodiazepines as antiproliferative agents
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US Patent 9399641 Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
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US Patent 9415117 Pyrrolobenzodiazepines and conjugates thereof
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US Patent 9624227 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases
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US Patent 9889207 Pyrrolobenzodiazepines and conjugates thereof
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US Patent 9931414 Pyrrolobenzodiazepine-antibody conjugates
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US Patent 11318211 Dosage regimes for the administration of an anti-CD19 ADC
Patent Primary Examiner
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Sheela J. Huff
CPC Code
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C07K 16/2803
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A61K 47/6849
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A61K 47/6803
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A61P 35/00

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