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US Patent 11697827 Systems and methods for gene modification

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 US Patent 11697827 Systems and methods for gene modification

Article

The present disclosure provides a method for designing a set of guide RNAs for hybridizing a genomic region of interest. The present disclosure further provides methods of editing at least one genomic region of interest with at least one set of guide RNAs.

Infobox
Is a
Patent
Patent
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Patent Applicant
Synthego
Synthego
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Current Assignee
Synthego
Synthego
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
116978270
Date of Patent
July 11, 2023
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Patent Application Number
171167910
Date Filed
December 9, 2020
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Patent Citations
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US Patent 7897737 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
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US Patent 8603996 Modular aptamer-regulated ribozymes
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US Patent 8697359 CRISPR-Cas systems and methods for altering expression of gene products
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US Patent 8771945 CRISPR-Cas systems and methods for altering expression of gene products
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US Patent 9567604 Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
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US Patent 9650617 CRISPR hybrid DNA/RNA polynucleotides and methods of use
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US Patent 9738908 CRISPR/Cas systems for genomic modification and gene modulation
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US Patent 9855297 Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system
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US Patent 10000772 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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US Patent 10106820 Methods and compositions for modifying a targeted locus
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US Patent 10119133 Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
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US Patent 10308961 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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US Patent 10329574 Methods for the identification of variant recognition sites for rare-cutting engineered double-strand-break-inducing agents and compositions and uses thereof
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US Patent 10337001 Guide RNA with chemical modifications
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US Patent 10337029 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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US Patent 10351878 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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US Patent 10354746 Methods and systems for identifying CRISPR/Cas off-target sites
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US Patent 10358658 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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US Patent 10358659 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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US Patent 10362771 Method for knock-in of DNA into target region of mammalian genome, and cell
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Patent Primary Examiner
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Catherine S Hibbert
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CPC Code
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C12N 2310/321
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C12N 2310/315
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C12N 2310/20
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C12N 15/11
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C12N 2800/80
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C12N 9/22
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