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US Patent 11422504 Multiple laminar flow-based particle and cellular separation with laser steering

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Is a
Patent
Patent
0

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
0
Patent Number
114225040
Patent Inventor Names
Jessica Shireman0
Joseph Plewa0
Lewis Gruber0
Neil Rosenbaum0
Daniel Mueth0
Amy Anderson0
Date of Patent
August 23, 2022
0
Patent Application Number
174589470
Date Filed
August 27, 2021
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Patent Citations
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US Patent 10180388 Scanning infrared measurement system
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US Patent 10216144 Multiple laminar flow-based particle and cellular separation with laser steering
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US Patent 10315194 Chip device and a particle analyzing apparatus
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US Patent 11187224 Microfluidic chip
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US Patent 11193879 Use of vibrational spectroscopy for microfluidic liquid measurement
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US Patent 11243494 Multiple laminar flow-based particle and cellular separation with laser steering
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US Patent 10025322 Fluid handling system for a fluid flow instrument
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US Patent 10029283 Method and apparatus for sorting particles
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...
Patent Citations Received
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US Patent 11873173 Multilayer hydrodynamic sheath flow structure
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Patent Primary Examiner
‌
Kiet T Nguyen
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CPC Code
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G01N 33/4915
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G01N 2015/0053
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G01N 2015/0233
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G01N 2015/0288
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G01N 2015/035
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G01N 2015/045
0
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G01N 2015/1025
0
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G01N 2015/1081
0
...

The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

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