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US Patent 10216144 Multiple laminar flow-based particle and cellular separation with laser steering

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Contents

Is a
Patent
Patent
0

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
0
Patent Number
102161440
Patent Inventor Names
Neil Rosenbaum0
Jessica Shireman0
Joseph Plewa0
Lewis Gruber0
Amy Anderson0
Daniel Mueth0
Date of Patent
February 26, 2019
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Patent Application Number
150998910
Date Filed
April 15, 2016
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Patent Citations Received
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US Patent 11965816 Use of vibrational spectroscopy for microfluidic liquid measurement
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US Patent 11628439 Single-sheath microfluidic chip
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US Patent 11639888 Microfluidic system and method with focused energy apparatus
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US Patent 11674882 Scanning infrared measurement system
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US Patent 11331670 Systems and methods for particle focusing in microchannels
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US Patent 11320361 Scanning infrared measurement system
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US Patent 11415503 Microfluidic system and method with focused energy apparatus
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US Patent 11415936 Multiple laminar flow-based particle and cellular separation with laser steering
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Patent Primary Examiner
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Kiet T Nguyen
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Patent abstract

The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

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