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Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Philippe Lefevre0
Alain Francois0
Baptiste Boit0
Damien Passe0
Date of Patent
June 21, 2022
0Patent Application Number
167482220
Date Filed
January 21, 2020
0Patent Primary Examiner
A process for preparing a coagglomerate of crystalline mannitol and of starch includes spray-drying or granulating a mixture of a “solution” of mannitol and of starch, the starch being suspended in the mannitol solution. The coagglomerate has a laser volume mean diameter D4,3 between 60 and 500 μm, and a mannitol/starch ratio is between 99.5/0.5 and 50/50. The coagglomerate, when mixed with 1.2% of magnesium stearate and formed into a cylindrical tablet with convex faces, a diameter of 13 mm, a thickness of 6 mm, and a weight of 0.734 g, has a crushing strength greater than 120 N. 100 g of said coagglomerate has a flow of between 3 and 15 seconds, measured according to European Pharmacopoeia 5.0, volume 1, 01/2005: 20916, section 2.9.1.6.
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