Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Annick Goergler0
Eric Andre Kusznir0
Fabian Dey0
Roger Norcross0
Date of Patent
February 22, 2022
0Patent Application Number
168093250
Date Filed
March 4, 2020
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides selected dihydrobenzimidazolones which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.
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