US Patent 11234993 Method for treatment of cellular senescence

Patent 11234993 was granted and assigned to National Yang-Ming University on February, 2022 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

National Yang-Ming University

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

112349930

Patent Inventor Names

Yun-Lian Lin0

Wei-Hsiang Hsu0

Yi-Jang Lee0

Yuan-Heng Tu0

Bing-Ze Lin0

Cheng-Han Tsai0

Chun-Yuan Chang0

Chung-Sheng Huang0

...

Date of Patent

February 1, 2022

Patent Application Number

168833800

Date Filed

May 26, 2020

Patent Primary Examiner

‌

Dale R Miller

Patent abstract

The present invention provides an alcohol extract of Ajuga taiwanensis Nakai ex Murata exhibits significant effects on inhibiting the senescence in human WI-38 lung fibroblasts and human dermal fibroblasts. Moreover, the alcohol extract of A. taiwanensis is able to suppress the expression of the cofilin-1, a protein involved in actin dynamics and cell morphology and found to be increased in senescent cells. Suppression effect of cell senescence by this herb extract is more efficient in mild concentration without over-inhibition of cell viability and growth.