Patent 11185592 was granted and assigned to C4 Therapeutics on November, 2021 by the United States Patent and Trademark Office.
This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.