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US Patent 11058725 CA2 compositions and methods for tunable regulation

Patent 11058725 was granted and assigned to Obsidian Therapeutics on July, 2021 by the United States Patent and Trademark Office.

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Patent Citations Received
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US Patent 12104178 DHFR tunable protein regulation
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Patent abstract

The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (IL15) payloads, as well as compositions and methods of use thereof.

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Patent Inventor Names
Celeste Richardson0
Colleen Foley0
Dexue Sun0
Dhruv Kam Sethi0
Geetha Hanna Mylvaganam0
James A. Storer0
Jennifer Leah Gori0
Jeremy Hatem Tchaicha0
Kutlu Goksu Elpek0
Meghan C. Langley0
Michelle Fleury0
Michelle Ols0
Molly Reed Perkins0
Scott Francis Heller0
Shyamsundar Subramanian0
Tucker Read Ezell0
Vipin Suri0
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Official Website
https://pdfpiw.uspto.gov/.piw?Docid=110587250
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Infobox
Is a
Patent
Patent
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Patent Applicant
Obsidian Therapeutics
Obsidian Therapeutics
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Current Assignee
Obsidian Therapeutics
Obsidian Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
110587250
Date of Patent
July 13, 2021
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Patent Application Number
170176700
Date Filed
September 10, 2020
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Official Website
https://pdfpiw.uspto.gov/.piw?Docid=110587250
Patent Citations
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US Patent 10040835 Vectors encoding rod-derived cone viability factor
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US Patent 10125193 Chimeric antigen receptors and methods of making
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US Patent 10137180 Methods for regulating protein function in cells in vivo using synthetic small molecules
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US Patent 10202433 IL-15 mutant polypeptides as IL-15 antagonists and encoding nucleic acids
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US Patent 10351612 Interleukin 15 as selectable marker for gene transfer in lymphocytes
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US Patent 10415017 Transgenic macrophages, chimeric antigen receptors, and associated methods
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US Patent 10428305 Modified natural killer cells that express IL15 and uses thereof
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US Patent 10472637 Gold optimized CAR T-cells
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US Patent 10570186 Chimeric antigen receptors (CAR) to selectively target protein complexes
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US Patent 10675305 Coordinating gene expression using RNA destabilizing elements
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US Patent 10688132 Coordinating gene expression using RNA destabilizing elements
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US Patent 10774311 Natural killer cells modified to express membrane-bound interleukin 15 and uses thereof
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Patent Primary Examiner
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Kevin K Hill
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