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US Patent 10428305 Modified natural killer cells that express IL15 and uses thereof

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Is a
Patent
Patent
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Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
104283050
Patent Inventor Names
David Shook0
Masaru Imamura0
Dario Campana0
Date of Patent
October 1, 2019
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Patent Application Number
153093620
Date Filed
May 14, 2015
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Patent Citations Received
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US Patent 12104178 DHFR tunable protein regulation
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US Patent 11473060 Compositions and methods for differentiating stem cells into NK cells
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US Patent 11058725 CA2 compositions and methods for tunable regulation
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US Patent 11661459 Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
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US Patent 11365236 Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy
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US Patent 11883432 Chimeric antigen receptor system with adaptable receptor specificity
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US Patent 12005081 Chimeric receptors and methods of use thereof
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US Patent 11459372 Gene-edited natural killer cells
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Patent Primary Examiner
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Claire Kaufman
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Patent abstract

The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

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