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US Patent 11028081 Dual mechanism inhibitors for the treatment of disease

Patent 11028081 was granted and assigned to Aerie Pharmaceuticals on June, 2021 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
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Patent attributes

Patent Applicant
Aerie Pharmaceuticals
Aerie Pharmaceuticals
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Current Assignee
Aerie Pharmaceuticals
Aerie Pharmaceuticals
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
110280810
Patent Inventor Names
Jill Marie Sturdivant0
Mitchell A. deLong0
Susan M. Royalty0
Date of Patent
June 8, 2021
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Patent Application Number
167300580
Date Filed
December 30, 2019
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Patent Citations
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US Patent 10568878 Combination therapy
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US Patent 10112920 Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
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US Patent 10174017 Dual mechanism inhibitors for the treatment of disease
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US Patent 10316029 Dual mechanism inhibitors for the treatment of disease
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US Patent 10588901 Combination therapy
Patent Citations Received
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US Patent 12018012 Aryl cyclopropyl-amino-isoquinolinyl amide compounds
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US Patent 11590123 Ophthalmic compositions
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US Patent 11618748 Dual mechanism inhibitors for the treatment of disease
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US Patent 11707460 Ophthalmic compositions
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US Patent 11891376 Aryl cyclopropyl-amino-isoquinolinyl amide compounds
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Patent Primary Examiner
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D Margaret M Seaman
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Patent abstract

Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.

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