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US Patent 10493035 Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

Patent 10493035 was granted and assigned to Global Blood Therapeutics on December, 2019 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent

Patent attributes

Patent Applicant
Global Blood Therapeutics
Global Blood Therapeutics
Current Assignee
Global Blood Therapeutics
Global Blood Therapeutics
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10493035
Date of Patent
December 3, 2019
Patent Application Number
15782381
Date Filed
October 12, 2017
Patent Citations
‌
US Patent 10034879 Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
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US Patent 10017491 Compounds and uses thereof for the modulation of hemoglobin
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US Patent 10137118 Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
Patent Citations Received
‌
US Patent 11396513 Compositions for activating pyruvate kinase
‌
US Patent 11014927 Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
‌
US Patent 11071725 Activating pyruvate kinase R
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US Patent 11649242 Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
0
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US Patent 10683285 Modulators of hemoglobin
‌
US Patent 11548880 Modulators of hemoglobin
‌
US Patent 11001588 Activating pyruvate kinase R and mutants thereof
Patent Primary Examiner
‌
Yong L Chu
Patent abstract

Provided herein are high strength/high drug load tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (“Compound 1”), dispersible tablets comprising Compound 1, processes of manufacturing such tablets, and methods for treating patients with the tablets. Compound 1 is useful for treating hematological disorders such as sickle cell disease, pulmonary disease such as idiopathic pulmonary fibrosis, and hypoxia and hypoxemia conditions.

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