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US Patent 11649242 Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators

Patent 11649242 was granted and assigned to FORMA Therapeutics on May, 2023 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

FORMA Therapeutics

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Current Assignee

FORMA Therapeutics

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Zhongguo Wang0

Anna Ericsson0

Bingsong Han0

Chase C. Smith0

David R. Lancia, Jr.0

David Richard0

Gary Gustafson0

Lorna Mitchell0

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Date of Patent

May 16, 2023

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Patent Application Number

172393640

Date Filed

April 23, 2021

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Patent Citations

US Patent 10077249 Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde

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US Patent 10004725 Methods of treatment

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US Patent 10017491 Compounds and uses thereof for the modulation of hemoglobin

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US Patent 10034879 Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation

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US Patent 10100040 Compounds and uses thereof for the modulation of hemoglobin

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US Patent 10100043 Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation

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US Patent 10208052 Compositions for activating pyruvate kinase

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US Patent 10266551 Compounds and uses thereof for the modulation of hemoglobin

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Patent Primary Examiner

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CPC Code

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The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

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