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US Patent 10435688 Oligonucleotide compounds for targeting huntingtin mRNA

Patent 10435688 was granted and assigned to University of Massachusetts on October, 2019 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Patent Applicant

University of Massachusetts

Current Assignee

University of Massachusetts

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

104356880

Patent Inventor Names

Anastasia Khvorova0

Julia Alterman0

Neil Aronin0

Date of Patent

October 8, 2019

Patent Application Number

156971200

Date Filed

September 6, 2017

Patent Citations Received

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US Patent 12077755 Bioactive conjugates for oligonucleotide delivery

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US Patent 11702659 Optimized anti-FLT1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders

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US Patent 11753638 Conjugated oligonucleotides

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US Patent 11767527 Modified oligonucleotides targeting SNPs

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US Patent 11993774 Huntingtin (HTT) iRNA agent compositions and methods of use thereof

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US Patent 12024706 Modified oligonucleotides targeting SNPs

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US Patent 11279930 O-methyl rich fully stabilized oligonucleotides

Patent Primary Examiner

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Tracy Vivlemore

Patent abstract

This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.

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