Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Sean Stevens0
Andrew J. Murphy0
Anthony T. Dore, Jr.0
Li-Hsien Wang0
Date of Patent
October 8, 2019
0Patent Application Number
160010740
Date Filed
June 6, 2018
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.
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