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US Patent 10272410 De novo synthesized gene libraries

Patent 10272410 was granted and assigned to Twist Bioscience on April, 2019 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Twist Bioscience
Twist Bioscience
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Current Assignee
Twist Bioscience
Twist Bioscience
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
102724100
Patent Inventor Names
Siyuan Chen0
Andres Fernandez0
Bill James Peck0
Pierre Indermuhle0
William Banyai0
Date of Patent
April 30, 2019
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Patent Application Number
148859650
Date Filed
October 16, 2015
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Patent Citations Received
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US Patent 12086722 DNA-based digital information storage with sidewall electrodes
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US Patent 11492727 Variant nucleic acid libraries for GLP1 receptor
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US Patent 11492728 Variant nucleic acid libraries for antibody optimization
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US Patent 11512347 Flexible substrates for nucleic acid synthesis
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US Patent 11691118 Devices and methods for oligonucleic acid library synthesis
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US Patent 11697668 Methods and devices for de novo oligonucleic acid assembly
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US Patent 11745159 Heated nanowells for polynucleotide synthesis
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US Patent 11332740 Methods for seamless nucleic acid assembly
...
Patent Primary Examiner
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Brian R. Gordon
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Patent abstract

Provided herein are devices for the manufacturing of high-quality oligonucleic acids. Longer nucleic acids, e.g., genes, can be synthesized in parallel using microfluidic assemblies described herein. Devices described herein include silicon plates having a plurality of channels in fluid communication with a plurality of microchannels. The number of microchannels and dimensions of the microchannels provide for rapid exchange of chemical exposure during de novo synthesis of oligonucleic acids.

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