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US Patent 10053688 De novo synthesized nucleic acid libraries

Patent 10053688 was granted and assigned to Twist Bioscience on August, 2018 by the United States Patent and Trademark Office.

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Patent
Patent

Patent attributes

Patent Applicant
Twist Bioscience
Twist Bioscience
Current Assignee
Twist Bioscience
Twist Bioscience
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10053688
Date of Patent
August 21, 2018
Patent Application Number
15682100
Date Filed
August 21, 2017
Patent Citations Received
‌
US Patent 12086722 DNA-based digital information storage with sidewall electrodes
0
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US Patent 11492727 Variant nucleic acid libraries for GLP1 receptor
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US Patent 11492728 Variant nucleic acid libraries for antibody optimization
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US Patent 11407837 GPCR binding proteins and synthesis thereof
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US Patent 12018065 Variant nucleic acid libraries for coronavirus
0
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US Patent 11492665 Polynucleotides, reagents, and methods for nucleic acid hybridization
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US Patent 11512347 Flexible substrates for nucleic acid synthesis
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US Patent 10384188 De novo synthesized gene libraries
...
Patent Primary Examiner
‌
Kaijiang Zhang
Patent abstract

Disclosed herein are methods for the generation of nucleic acid libraries encoding for gRNA sequences. The gRNAs encoded by methods described herein may be single or double gRNA sequences. Methods described provide for the generation of gRNA libraries, as a DNA precursor or as a RNA transcription product, with improved accuracy and uniformity.

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