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US Patent 10041073 Reduced size self-delivering RNAi compounds

Patent 10041073 was granted and assigned to Rxi Pharmaceuticals Corporation on August, 2018 by the United States Patent and Trademark Office.

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Patent Citations Received
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US Patent 11926828 Methods for treating aging and skin disorders using nucleic acids targeting TYR or MMP1
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Patent abstract

The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing. The RNAi constructs may be, for instance, miRNA constructs that are miRNA modulators.

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Patent Inventor Names
Anastasia Khvorova0
Dmitry Samarsky0
James Cardia0
Joanne Kamens0
Tod M. Woolf0
William Salomon0
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US Patent 11396654 Neutral nanotransporters
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Patent Citations Received
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US Patent 10934550 Immunotherapy of cancer
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Infobox
Is a
Patent
Patent
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Current Assignee
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Rxi Pharmaceuticals Corporation
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
100410730
Date of Patent
August 7, 2018
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Patent Application Number
130697800
Date Filed
March 23, 2011
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Patent Citations Received
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US Patent 10240149 Reduced size self-delivering RNAi compounds
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US Patent 10300027 Effective sensitizing dose of a gelled immunomodulating topical composition
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US Patent 10479992 RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
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US Patent 10633654 Modified RNAi polynucleotides and uses thereof
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US Patent 10662430 RNA interference in ocular indications
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US Patent 10774330 Reduced size self-delivering RNAI compounds
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US Patent 10792298 MiRNA pharmaceutical compositions and therapeutic uses thereof
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US Patent 10808247 Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
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US Patent 10815485 RNA interference in skin indications
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US Patent 10876119 Reduced size self-delivering RNAI compounds
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US Patent 10900039 Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
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US Patent 10913948 RNA interference in dermal and fibrotic indications
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US Patent 10934550 Immunotherapy of cancer
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US Patent 11001845 Nucleic acid molecules targeting superoxide dismutase 1 (SOD1)
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US Patent 11021707 Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
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US Patent 11254940 Inhibition of MAP4K4 through RNAi
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US Patent 11279934 Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
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US Patent 11396654 Neutral nanotransporters
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US Patent 11584933 RNA interference in ocular indications
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Patent Primary Examiner
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J. E. Angell
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Patent Citations Received
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US Patent 11584933 RNA interference in ocular indications
0
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Patent Citations Received
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US Patent 10934550 Immunotherapy of cancer
0

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