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US Patent 10041073 Reduced size self-delivering RNAi compounds

Patent 10041073 was granted and assigned to Rxi Pharmaceuticals Corporation on August, 2018 by the United States Patent and Trademark Office.

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Patent attributes

Current Assignee

Rxi Pharmaceuticals Corporation

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Dmitry Samarsky0

Tod M. Woolf0

William Salomon0

Anastasia Khvorova0

James Cardia0

Joanne Kamens0

Date of Patent

August 7, 2018

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Patent Application Number

130697800

Date Filed

March 23, 2011

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Patent Citations Received

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US Patent 11254940 Inhibition of MAP4K4 through RNAi

US Patent 11279934 Methods for treating cancer using nucleic acids targeting MDM2 or MYCN

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Patent Primary Examiner

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Patent abstract

The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing. The RNAi constructs may be, for instance, miRNA constructs that are miRNA modulators.

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