Prellis Biologics, founded in 2016 by research scientists Melanie Matheu and Noelle Mullin, is a San Francisco-based 3D tissue printing company. In June 2018 they announced that they had reached record speed and resolution in the printing of human tissue with viable capillaries.
Prellis' holographic 3D printing technology can create the microvascular and scaffolding that allows human tissue to survive. Tissue that is densely packed with cells will die in less than 30 minutes unless oxygen and nutrients can be supplied immediately, through capillaries. Capillaries are about 5 to 10 microns in diameter and Prellis' technology can print with resolutions as small as 0.5 microns.
The first transplantable human tissues Prellis Biologics is working to develop are the insulin secreting units of the pancreas, Islets of Langerhans for people with Type 1 Diabetes Mellitus (T1DM).
Prellis Biologics has technology to bioprint human mini lymph nodes, part of the immune system that produces antibodies. In 2017 their mini lymph nodes were injected with Zika virus and produced human antibodies for passive immunity against Zika. The same methods are being used to develop antibodies for passive immunity against the SARS-CoV-2 virus responsible for COVID-19. The process takes two weeks to grow lymph nodes, a month of screening antibodies, with clinical trials possible in 10 weeks.
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- Cluster: Synthetic biologyA cluster of topics related to synthetic biology.
- CompanyA company, abbreviated 'co.', is a legal entity made up of an association of people, be they natural, legal, or a mixture of both, for carrying on a commercial or industrial enterprise.
- Cluster: COVID-19A cluster of topics related to COVID-19. COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2. COVID-19 was first detected in Wuhan City, China and the outbreak was declared a pandemic on March 11, 2020 by the WHO.
- Tissue engineeringTissue Engineering is a multidisciplinary scientific field working on the development of lab grown tissues, such as organs, muscle tissues, or specific cell types, by combining expertise from synthetic biology, molecular biology, biology, chemistry, material science, and mathematics.
- 3D printingAdditive process used to make a three-dimensional object
- IndieBioA startup accelerator for biotechnology companies located in San Francisco, California.