Gatehouse Bio

Gatehouse Bio

A bio-data company that uses AI to analyze RNA sequencing data to identify small RNA biomarkers

Gatehouse Bio is a bio-data company. Gatehouse Bio has a collaboration with AstraZeneca for the identification of new targets for respiratory and cardiovascular diseases using Gatehouse Bio’s AI-powered platform. The sRNAlytics platform identifies small RNA (sRNA) signatures in sequencing data and points to molecular pathways that correlate to or potentially drive disease. The company’s annotation library has more than 1.4 small RNA features that their machine learning algorithms use to recognize signals. Gatehouse joined AstraZeneca’s Boston Bio Hub Incubator in 2018.

The sRNA signatures discovered by GateHouse’s platform are biomarkers for disease, which can assist with classifying patients for clinical trials. As a proof-of-concept, GateHouse Bio used their sRNAlytics platform in collaboration with academic researchers to identify and validate biomarkers to identify pre-symptomatic and symptomatic Huntington’s disease.

COVID-19

Gatehouse Bio proposed using their technology platform in a study to study patient response sRNA signatures to COVID-19 disease which is caused by infection with the coronavirus SARS-CoV-2. The company will correlate their sRNA signatures that define biological processes affected by SARS and MERS to SARS-CoV-2. The study will analyze sRNA signatures correlated to inflammation, cytokine release, T-cell activation and fibrosis. Gatehouse expects to find host pathways impacted by SARS-CoV-2 infection and use this information to search their database of FDA approved drugs to accelerate the identification of potentially effective drugs. The sRNA signatures in patients with COVID-19 disease could be used as a prognostic test as well. Gatehouse Bio will analyze sRNA signatures correlated to inflammation, cytokine release, T-cell activation and fibrosis.

Timeline

People

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David W. Salzman

Founder, CEO

Neal Foster

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