Aranex Biotech

Aranex Biotech, Inc. is a Canadian agriculture startup based in Ireland. Founded in April 2015, Aranex Biotech is working to make "hypoallergenic peanuts."

Aranex Biotech, Inc. is a Canadian synthetic agriculture startup based in Ireland. Founded in April 2015, Aranex Biotech is working to make "hypoallergenic peanuts." At its 2015 initiation, Aranex Biotech, Inc. was provided with seed funding by IndieBio, a subgroup of American venture capital group SOSV. CEO Chloe Gui then presented the concept at the 2015 IndieBio EU Demo Day, drawing the interest of another SOSV accelerator RebelBio. University College Cork, where Aranex Biotech laboratories are based, has partnered with IndieBio as part of an accelerator program for up and coming food developers.

Peanuts allergies are one of the most prevalent types of food allergies, and are capable of causing life-threatening anaphylactic reactions. Peanut allergies are commonly diagnosed in children less than 2 years old, and are the food allergy least likely resolve with age. A recent review by Bunyavanich et al. looked at diagnoses of peanut allergies between 1997 and 2007 and found that in children under the age of 18, the prevalence of the peanut allergy more than doubled, and since then, the upward trend has continued, an estimated twenty percent. Experts predict that this number will continue to rise, though the exact reason for this increase is unclear. There have been some studies to suggest that lifestyle may play a role. A 2012 study found a higher incidence of food allergies in children living in cities compared to more rural areas.

According to Aranex CEO Chloe Gui, most other companies that are working to reduce peanut allergies have been focused on controlling the RNA or proteins from the culprit genes. She thinks the novelty of her company is that they are looking to develop genetically modified plants using CRISPR-Cas9 gene editing to completely remove three major allergenic genes from the plant. As of 2018, there were no available patents on their process or products, but Chloe Gui states that they plan to begin field test and clinical safety trial and seek regulatory approval starting in 2018.

Aranex Biotech plans to market their products specifically to farmers, with an ultimate goal of replacing traditional peanut crops. They also plan to work with companies that consume large quantities of peanuts to set up partnerships. They have already begun talks with Mars and the Hershey Company.

From Chloe Gui's 2015 IndieBio EU Demo Day

According to Aranex Biotech, one of their biggest hurdles will be whether they can continue to procure funding depending on whether CRISPR developed peanuts are considered GMO crops. There are different criteria in different countries that determine whether crops are labeled "GMO". Additionally, should Aranex's products be labeled GMO, they may face the same scrutiny and backlash that many GMO crops have faced, making it difficult for them to break into the market.

In 1990, scientists identified the primary allergen in peanut plants, opening the doors for research into treatment and prevention. Since then, a handful of other genes have also been elucidated, and scientists are closer to understanding why peanuts evoke such a strong allergic reaction. Some food scientistscientists have moved toward attempting to attenuate the allergens, making peanut products safer for consumers with allergies. A food bioprocessing company known as Alrgn Bio developed an "product cleansing" enzymatic process that uses the enzyme Alcalase to inactivate the proteins in various peanut food products. Another group of food scientists led by Peggy Ozias-Akins used small interfering RNAS (siRNAs) to genetically modify peanut plants. Her experiments yielded plants with reduced levelsHere ofare twosome of the primarythose allergens.endeavors:

• A food bioprocessing company known as Alrgn Bio developed an "product cleansing" enzymatic process that uses the enzyme Alcalase to inactivate the proteins in various peanut food products.
• Another group of food scientists from the University of Georgia led by Peggy Ozias-Akins used small interfering RNAS (siRNAs) to genetically modify peanut plants. Her experiments yielded plants with reduced levels of two of the primary allergens.
• Plant biologist Hortense Dodo runs agricultural biotech IngateyGen, which uses genetic engineering to generate hypoallergenic peanuts for commercial sale. Although most of their products are modified peanuts, their company interest in to improve human health and nutrition, and they are also working on a fortified yam.

Aranex Biotech, Inc. is a Canadian agriculture startup based in Ireland. Founded in April 2015, Aranex Biotech is working to make "hypoallergenic peanuts."

Peanuts allergies are one of the most prevalent types of food allergies, and are capable of causing life-threatening anaphylactic reactions. Peanut allergies are commonly diagnosed in children less than 2 years old, and are the food allergy least likely resolve with age. A recent review by Bunyavanich et al. looked at diagnoses of peanut allergies between 1997 and 2007 and found that in children under the age of 18, the prevalence of the peanut allergy more than doubled, and since then, the upward trend has continued, an estimated twenty percent. Experts predict that this number will continue to rise, though the exact reason for this increase is unclear. There have been some studies to suggest that lifestyle may play a role. A 2012 study found a higher incidence of food allergies in children living in cities compared to more rural areas.

Peanut allergies have created substantial social difficulties. Because of the potential severity of the reaction, many schools have banned all kinds of peanut products from schools, while psychology experts have proposed that children with food allergies have a more difficult time making friends and assimilating into their class. Other studies show that there is an economic impact: families that have one or more members with a food allergy spend on average $1,000 more on food each year. Outside of social difficulties, studies have found that food allergies including peanut allergies can lead to growth defects in children, and a study on quality of life found that parents of children with food allergies suffered more anxiety and a decreased quality of life compared with parents of allergy-free children.

In 1990, scientists identified the primary allergen in peanut plants, opening the doors for research into treatment and prevention. Since then, a handful of other genes have also been elucidated, and scientists are closer to understanding why peanuts evoke such a strong allergic reaction. Some food scientist have moved toward attempting to attenuate the allergens, making peanut products safer for consumers with allergies. A food bioprocessing company known as Alrgn Bio developed an "product cleansing" enzymatic process that uses the enzyme Alcalase to inactivate the proteins in various peanut food products. Another group of food scientists led by Peggy Ozias-Akins used small interfering RNAS (siRNAs) to genetically modify peanut plants. Her experiments yielded plants with reduced levels of two of the primary allergens.

Aranex Biotech, Inc. is a Canadian agriculture startup based in Ireland. Founded in April 2015, Aranex Biotech is working to make "hypoallergenic peanuts".