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Amydis Diagnostics Inc. SBIR Phase I Award, August 2022

A SBIR Phase I contract was awarded to Amydis Diagnostics in August, 2022 for $458,527.0 USD from the U.S. Department of Health & Human Services and National Institutes of Health.

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sbir.gov/node/2339089
Is a
SBIR/STTR Awards
SBIR/STTR Awards

SBIR/STTR Award attributes

SBIR/STTR Award Recipient
Amydis Diagnostics
Amydis Diagnostics
0
Government Agency
0
Government Branch
National Institutes of Health
National Institutes of Health
0
Award Type
SBIR0
Contract Number (US Government)
1R43AG078075-010
Award Phase
Phase I0
Award Amount (USD)
458,5270
Date Awarded
August 15, 2022
0
End Date
July 31, 2023
0
Abstract

Project SummaryAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) define two ends of a spectrum of clinically, genetically, and mechanistically related neurodegenerative diseases. Due to symptom overlaps with other diseases, the early and accurate diagnosis of ALS and FTD is challenging. This leads to delayed intervention and stands as a major barrier to the efficient clinical testing of new disease-modifying therapeutics. Efforts to develop new therapies and apply them early would be greatly facilitated by biomarkers that reveal the state of ALS/FTD pathogenesis in vivo at the molecular level. Currently there are no objective diagnostics to non-invasively detect and measure the most defining molecular feature of ALS/FTD pathogenesis: accumulation of deposits of the TAR DNA-binding protein 43 (TDP43). A buildup of TDP43 deposits occurs in ~97% of ALS and ~50% of FTD cases and is thought to be a central driver of disease pathogenesis. This proposal will generate proof of concept for an affordable, accessible and innovative approach to detect and quantify TDP43 pathology in ALS/FTD human eyes using patent protected small molecule fluorescent retinal contrast agents.

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