Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
James L. Kirkland0
Tamar Tchkonia0
Darren J. Baker0
Jan M. A. van Deursen0
Date of Patent
May 15, 2018
Patent Application Number
14792208
Date Filed
July 6, 2015
Patent Citations Received
Patent Primary Examiner
Patent abstract
This document provides a transgenic mouse for studying the role of senescent cells in an age-related phenotype. A recombinant polypeptide is expressed in senescent cells under control of a p16INK4a promoter. The polypeptide can be triggered to directly induce cell death in senescent cells. As a result, progression of one or more age-related phenotypes is delayed in the mouse. An example is the INK-ATTAC mouse which also expresses a marker polypeptide in senescent cells.
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