A method of manufacturing a bottom gusseted pouch is provided. The method comprises unwinding a pouch webbing in a first flow direction, the pouch webbing defining front and back panels; inserting a gusset webbing between the panels in a second flow direction; attaching the gusset webbing to the panels to form a bottom gusseted end; optionally inserting a closure mechanism between the panels in a third flow direction; attaching the closure mechanism to the panels to form the resealable top end of the pouch; sealing the side edges of the panels to complete the pouch; and optionally cutting the completed pouch from the pouch webbing. At least one of the pouch webbing and the gusset webbing is formed of a supported film.