Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Anusha Dias0
Frank DeRosa0
Michael Heartlein0
Shirang Karve0
Date of Patent
May 1, 2018
Patent Application Number
14775915
Date Filed
March 14, 2014
Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of subjecting an impure preparation comprising in vitro synthesized mRNA to a denaturing condition, and purifying the mRNA from the impure preparation from step (a) by tangential flow filtration, wherein the mRNA purified from step (b) is substantially free of prematurely aborted RNA sequences and/or enzyme reagents used in in vitro synthesis.
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