US Patent 9938326 Pneumococcal vaccine containing pneumococcal surface protein A

A pneumococcal vaccine comprising a fusion protein at least comprising a full-length family 1 pneumococcal surface protein A (PspA) or a fragment thereof, and a full-length family 2 PspA or a fragment thereof, in particular any one of the following fusion proteins (1) to (3):(1) a fusion protein at least comprising a family 1, clade 2 PspA and a family 2, clade 3 PspA,(2) a fusion protein at least comprising a family 1, clade 2 PspA and a family 2, clade 4 PspA, and(3) a fusion protein at least comprising a family 1, clade 2 PspA and a family 2, clade 5 PspA,is useful as a pneumococcal vaccine comprising a single protein antigen that has broadly cross-reactive immunogenicity and can induce immune response against a wide range of pneumococcal clinical isolates.