An improved article of footwear and a related method of manufacture are provided. The article of footwear can include a sole construction including a midsole and an outsole that are configured to promote the natural motion of the wearer's foot and conformance to the ground. The sole construction can additionally include an insole construction having enhanced flexibility in the forefoot region to further accommodate dorsi-flexion and plantar-flexion of the wearer's foot. The related method of manufacture provides the assembly of an article of footwear having these and other features, which can be suitable for athletic wear, outdoor wear and casual wear by adults, adolescents and small children.