Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Mark Aaron Behlke0
Ashley Mae Jacobi0
Garrett Richard Rettig0
Michael Allen Collingwood0
Mollie Sue Schubert0
Date of Patent
December 12, 2017
0Patent Application Number
149757090
Date Filed
December 18, 2015
0Patent Citations Received
0
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Patent Primary Examiner
Patent abstract
This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified forms of crRNA and tracrRNA are described for use as a reconstituted guide RNA for interaction with Cas9 of CRIPSR systems. The resultant length-modified and chemically-modified forms of crRNA and tracrRNA are economical to produce and can be tailored to have unique properties relevant to their biochemical and biological activity in the context of the CRIPSR Cas9 endonuclease system.
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