US Patent 9827298 Neurotoxins exhibiting shortened biological activity
Patent 9827298 was granted and assigned to Merz Pharma on November, 2017 by the United States Patent and Trademark Office.
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The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a Neurotoxin polypeptide exhibiting a reduced duration of biological effect in a subject, wherein the polypeptide comprises at feast one degradation signal in the light chain as well as vectors and host calls comprising the polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising the polynucleotides and polypeptides as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments.
US Patent 09827298 Neurotoxins exhibiting shortened biological activity US Patent 9827298 Neurotoxins exhibiting shortened biological activity
US Patent 09827298 Neurotoxins exhibiting shortened biological activity
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