The present disclosure relates to an electric orifice cleaning brush including a brush head, a brush head mounting platform onto which the brush head is detachably mounted, and a motor holder for supporting the brush head mounting platform and accommodating a motor. The brush head includes a bristle implanting portion in the shape of a truncated cone and comprising a center region and bristles formed in bristle bindles. The bristle bindles are disposed outside the center region of the bristle implanting portion and are radially distributed in an evenly spaced manner. By means of the present disclosure, a complete cleaning of an orifice of a human body can be achieved, and damages to the orifice can be avoided.