Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Mika Aoyagi-Scharber0
Melita Dvorak-Ewell0
Teresa Margaret Christianson0
Shinong Long0
Daniel J. Wendt0
Daniel Solomon Gold0
Jonathan LeBowitz0
Date of Patent
September 26, 2017
0Patent Application Number
148832110
Date Filed
October 14, 2015
0Patent Primary Examiner
Patent abstract
The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.
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