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US Patent 9714419 PEGylated tyrosyl-tRNA synthetase polypeptides

Patent 9714419 was granted and assigned to aTyr Pharma on July, 2017 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors

Is a

Patent

Patent attributes

Current Assignee

aTyr Pharma

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

97144190

Patent Inventor Names

John D. Mendlein0

Jeffrey D. Watkins0

Ying Ji Buechler0

Minh-Ha Do0

Alain P. Vasserot0

Chi-Fang Wu0

Date of Patent

July 25, 2017

Patent Application Number

142375440

Date Filed

August 8, 2012

Patent Primary Examiner

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Kagnew H Gebreyesus

Patent abstract

The present invention provides PEGylated tyrosyl-tRNA synthetase (YRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The PEGylated YRS polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-PEGylated YRS polypeptides.