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US Patent 9556167 TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs)

Patent 9556167 was granted and assigned to Yale University on January, 2017 by the United States Patent and Trademark Office.

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Is a
Patent
Patent

Patent attributes

Patent Applicant
Yale University
Yale University
Current Assignee
Yale University
Yale University
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
9556167
Patent Inventor Names
David Spiegel0
Kelly Fitzgerald0
Date of Patent
January 31, 2017
Patent Application Number
14397995
Date Filed
May 1, 2013
Patent Citations Received
‌
US Patent 11931430 Labeled inhibitors of prostate specific membrane antigen (PSMA) as agents for the treatment of prostate cancer
0
‌
US Patent 12083181 Bi-functional molecules to degrade circulating proteins
0
‌
US Patent 11951190 Use of labeled inhibitors of prostate specific membrane antigen (PSMA), as agents for the treatment of prostate cancer
0
Patent Primary Examiner
‌
Rei Tsang Shiao
Patent abstract

The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.

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