US Patent 9540436 Use of antibodies for detection of IL-10

Patent 9540436 was granted and assigned to Biotest AG on January, 2017 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Patent Applicant

Biotest AG

Current Assignee

Biotest AG

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

9540436

Date of Patent

January 10, 2017

Patent Application Number

14591133

Date Filed

January 7, 2015

Patent Primary Examiner

‌

Shulamith H. Shafer

Patent abstract

Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL-10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.