Patent 9486446 was granted and assigned to Takeda Pharmaceutical Company on November, 2016 by the United States Patent and Trademark Office.
The present invention provides an orally-disintegrating solid preparation comprising fine granules showing controlled release of a pharmaceutically active ingredient, wherein the outermost layer of the fine granules is coated with a coating layer comprising hydroxypropylmethylcellulose and low-substituted hydroxypropylcellulose and breakage of the fine granules during tableting is suppressed.