Patent 9458205 was granted and assigned to Sangamo Biosciences Inc. on October, 2016 by the United States Patent and Trademark Office.
Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.