Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Anjana Rao0
Aravind Iyer0
Kian Peng Koh0
Mamta Tahiliani0
Suneet Agarwal0
Date of Patent
September 20, 2016
0Patent Application Number
137957390
Date Filed
March 12, 2013
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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