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US Patent 9347815 Single-protein nanomechanical mass spectrometry in real time

Patent 9347815 was granted and assigned to California Institute of Technology on May, 2016 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
California Institute of Technology
California Institute of Technology
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Current Assignee
California Institute of Technology
California Institute of Technology
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
93478150
Patent Inventor Names
Scott Kelber0
Akshay Naik0
Mehmet Selim Hanay0
Michael L. Roukes0
Date of Patent
May 24, 2016
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Patent Application Number
138900870
Date Filed
May 8, 2013
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Patent Citations Received
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US Patent 11754486 Systems and methods for measuring properties of particles
Patent Primary Examiner
‌
Edward Raymond
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Patent abstract

Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, where during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (G) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one. Complex protein mixtures can be analyzed at high sensitivity and resolution.

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