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US Patent 9347065 Methods to improve vector expression and genetic stability

Patent 9347065 was granted and assigned to International AIDS Vaccine Initiative on May, 2016 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
International AIDS Vaccine Initiative
International AIDS Vaccine Initiative
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Current Assignee
International AIDS Vaccine Initiative
International AIDS Vaccine Initiative
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
93470650
Patent Inventor Names
Xinsheng Zhang0
Maria J. Chiuchiolo0
Simon Hoffenberg0
Svetlana Rabinovich0
Aaron J. Wilson0
Arban Domi0
Christopher L. Parks0
Christy K. Jurgens0
...
Date of Patent
May 24, 2016
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Patent Application Number
137921030
Date Filed
March 10, 2013
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Patent Primary Examiner
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Nancy J Leith
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Patent abstract

The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.

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