A mattress protector includes upper and lower central portions connected respectively to an upper end and a lower end of a peripheral portion. Each of the upper and lower central portions has a TPU lining layer on the inner side. The peripheral portion has a TPU lining layer on the inner side and a PU shell layer on the outer side. The peripheral portion also has a waterproof zipper in its middle section. The contact areas of the two central portions and of the peripheral portion are connected together by a laminator through a hot pressing process to form the hollow mattress protector. The TPU lining layers on the inner side of the mattress protector are fused together to form a sealed and gap-free inner structure.