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US Patent 9200007 Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors

Patent 9200007 was granted and assigned to Karus Therapeutics on December, 2015 by the United States Patent and Trademark Office.

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Current Assignee
Karus Therapeutics
Karus Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
92000070
Date of Patent
December 1, 2015
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Patent Application Number
133881640
Date Filed
August 19, 2010
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Patent Citations Received
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US Patent 11779586 Compounds comprising tricyclic heterocyclic compounds
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US Patent 11708378 Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
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Patent Primary Examiner
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Rebecca Anderson
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Patent abstract

Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N—H, N-(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is (LQ)mY; and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110δ, and therefore have utility in therapy.

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