Cyber defense systems and methods protect an enterprise system formed of a plurality of networked components. Connectivity and relationship information indicative of connectivity and behavior of the components are collected. A relationship graph is created based upon the connectivity data and the relationship data, wherein nodes of the relationship graph represent the components and edges of the graph represent connectivity and relationships. At least part of the relationship graph is stored to form a chronology. The relationship graph and the chronology are analyzed to predict connectivity and relationship changes within the enterprise system, and a first anomaly is identified when the current connectivity and relationships do not match the prediction.