US Patent 9182387 Methods for cancer detection, diagnosis and prognosis

Patent 9182387 was granted and assigned to California Institute of Technology on November, 2015 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors Activity

Is a

Patent

Patent attributes

Current Assignee

California Institute of Technology

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

9182387

Date of Patent

November 10, 2015

Patent Application Number

14020313

Date Filed

September 6, 2013

Patent Citations Received

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US Patent 12104174 Methods relating to intestinal organ-on-a-chip

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US Patent 11884938 Cell culture system

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US Patent 11976304 Methods relating to intestinal organ-on-a-chip

Patent Primary Examiner

Alfred Worden

Patent abstract

The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.