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US Patent 9132146 Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine

Patent 9132146 was granted and assigned to Gradalis, Inc. on September, 2015 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors

Is a

Patent

Patent attributes

Current Assignee

Gradalis, Inc.

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

9132146

Date of Patent

September 15, 2015

Patent Application Number

12973823

Date Filed

December 20, 2010

Patent Primary Examiner

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Dana Shin

Patent abstract

Compositions and methods for cancer treatment are discloses herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.