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US Patent 9044514 Lipid-peptide-polymer conjugates and nanoparticles thereof

Patent 9044514 was granted and assigned to Regents of the University of California on June, 2015 by the United States Patent and Trademark Office.

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Current Assignee
Regents of the University of California
Regents of the University of California
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
9044514
Date of Patent
June 2, 2015
Patent Application Number
13610637
Date Filed
September 11, 2012
Patent Citations Received
‌
US Patent 12116461 Host-guest interactions for pa superstructure formation
0
‌
US Patent 11998589 PEGylated peptide amphiphile nanofibers and methods of use
0
Patent Primary Examiner
‌
Maury Audet
Patent abstract

The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.

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