A vibration dampened barrel for a crossbow preferably includes at least two vibration dampening chambers, which extend at least a portion of a length of the vibration dampened barrel. The at least two vibration dampening chambers are at least partially filled with a vibration dampening material, such as silicone, rubber, low density foam, high density foam, or any other suitable material that absorbs noise and or vibration. The vibration dampening material is preferably applied by injection, compression, spray, pouring or any other suitable method. The vibration dampening material is retained in the at least two vibration dampening chambers by curing or hardening; mechanically confinement including the use of fasteners or a plug; or with any other suitable method. The at least two vibration dampening chambers may be partially or fully filled. The vibration dampening material may also be placed on a surface inside an extruded barrel.